A Physiologically-Based Pharmacokinetic Model for Vancomycin by

Vancomycin is an antibiotic used for the treatment of systemic infections. It is given intravenously usually every twelve or twenty-four hours. This particular drug has a medium level of boundedness, with approximately fifty to sixty percent of the drug being free and thus physiologically effective. A physiologically-based pharmacokinetic (PBPK) model was used to better understand the absorption, distribution, and elimination of the drug. Using optimal parameters, the model could be used in the future to test how various factors, such as body mass index (BMI) or excretion levels, might affect the concentration of the antibiotic.